Clinical Trials

The NuralyteTM photonic analgesia / anaesthesia device has been successfully tested in five human clinical trials demonstrating efficacy and safety.

  • In the first three randomised single blinded clinical trials, NuralyteTM has been able to significantly raise the electric pulp testing (EPT) threshold into levels sufficient to induce pre-emptive analgesia (anaesthesia) when compared to three control diode laser devices.

  • In the fourth and fifth clinical trials, NuralyteTM was significantly superior to topical anaesthetic gel in eliminating or reducing the pain associated with dental needle injection.

  • After 60 seconds of exposure to the rays of NuralyteTM, pre-emptive analgesia (anaesthesia) was induced in human teeth in less than 2 minutes and lasted for around 20 minutes

  • The NuralyteTM device is straightforward to use in dental settings and no particular training is required for dental staff.


    Related scientific publications/citations:
    Kulkarni S, Walsh LJ, Bhurani Y, George R: Assessment of the onset of analgesia and length of analgesia following the use of PBM with different wavelengths: a clinical study. Lasers Med Sci 39, 236 (2024) DOI: 10.1007/s10103-024-04184-y